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In this issue of Science Signaling, Temprine et al report that up-regulation of the translesion DNA polymerase Polκ mediates resistance to BRAF pathway-targeted inhibitors and starvation in melanoma cells. These results exemplify the role that Polκ plays in cellular adaptation to stress. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.


Joann B Sweasy. DNA polymerase κ: Friend or foe? Science signaling. 2020 Apr 28;13(629)

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PMID: 32345726

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