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On a New Proposed Mechanism of 5-Fluorouracil-Mediated Cytotoxicity.

Shobbir Hussain

Trends in cancer 2020 May


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    The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5 methyltransferase (U5MT), TRMT2A, and its interaction with 5-FU metabolites incorporated within tRNAs, lead to an additional hypothesis that is proposed here. Copyright © 2020 Elsevier Inc. All rights reserved.

    Citation

    Shobbir Hussain. On a New Proposed Mechanism of 5-Fluorouracil-Mediated Cytotoxicity. Trends in cancer. 2020 May;6(5):365-368

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    PMID: 32348733

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