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We herein report five patients with nasal mucosa and sinus involvement who were diagnosed with immunoglobulin G4-related disease (IgG4-RD). In all cases, the lacrimal, parotid, and submandibular glands were swollen; biopsies of these glands were risky, so the labium and nasal mucosa were instead targeted. All patients tested positive through these biopsies, suggesting alternative sites for confirming IgG4-RD. These five patients had first been diagnosed and unsuccessfully treated for allergic rhinitis or chronic sinusitis. After the IgG4-RD diagnosis, they were administered corticosteroid therapy, which drastically improved the nasal mucosa and sinus involvement. When refractory allergic rhinitis or sinusitis is detected, IgG4-RD should be considered.


Masanobu Ueno, Kazuhisa Nakano, Ippei Miyagawa, Yoshiya Tanaka. Five Cases of IgG4-related Disease with Nasal Mucosa and Sinus Involvement. Internal medicine (Tokyo, Japan). 2020 Apr 30;59(15):1905-1911

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PMID: 32350195

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