SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53.

Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis and high mortality. To identify key genes associated with HCC and the underlying mechanisms, we performed weighted correlation network analysis (WGCNA) of potential key genes of HCC. We identified 17 key genes closely related to HCC by yellow module combined with PPI analysis. Verification of the role of these genes revealed that SPC25 knockdown results in a significant decrease in proliferation and metastasis of HCC cells and increased protein levels of components of the p53 pathway in vitro. In summary, we identified that SPC25 is a potential tumor-promoting factor in HCC and may act via the p53 pathway. © 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

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Fengjuan Chen, Ka Zhang, Yilin Huang, Fang Luo, Kunpeng Hu, Qingxian Cai. SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53. FEBS open bio. 2020 Jul;10(7):1261-1275

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PMID: 32351050

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