The contribution of plasma oxysterols in the challenging diagnostic work-up of infantile cholestasis.

Clinica chimica acta; international journal of clinical chemistry 2020 Aug

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Infantile cholestasis (IC) is defined as an impairment of bile production or flow occurring in the first months of life. The diagnostic approach in IC is challenging since the differential diagnosis is broad. We retrospectively evaluated 91 cholestatic infants referred to our department from 2014 to 2019. Patients with cholestasis underwent a complete IC diagnostic work-up including quantification of plasma oxysterols 7-ketocholesterol (7-KC) and cholestan-3β,5α,6β-triol (C-Triol). Oxysterols concentrations were mildly elevated in IC compared to control population. 7-KC and C-Triol plasma levels presented a linear relationship between them and with Spleen-Z score. Patients with NP-C showed the highest concentrations of both oxysterols compared with other etiologies of IC. Excluding NP-C patients, oxysterols concentrations were similar among all other etiological groups with no correlations found between them and the levels of cholesterol and bilirubin. ROC analysis identified AUCs of 1.0 for both oxysterols in predicting NP-C. Infants with IC should undergo a stepwise evaluation in which detailed clinical and deep analytical assessments are the main crossroads. Plasma oxysterols, a simple, reliable, and convenient diagnostic test should be included in the first steps of the diagnostic process in IC. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Andrea Pietrobattista, Silvio Veraldi, Manila Candusso, Maria Sole Basso, Daniela Liccardo, Claudia Della Corte, Antonella Mosca, Tommaso Alterio, Elisa Sacchetti, Giulio Catesini, Federica Deodato, Sara Boenzi, Carlo Dionisi-Vici. The contribution of plasma oxysterols in the challenging diagnostic work-up of infantile cholestasis. Clinica chimica acta; international journal of clinical chemistry. 2020 Aug;507:181-186