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    In this study, an original method of macromolecular design was used to develop a hyaluronidase-1 (HYAL1) inhibitor from its principal substrate, hyaluronic acid (HA). HA-based nanoparticles (HA-NP) were obtained by copolymer self-assembly and their effects on HYAL1 activity were investigated by combining different analytical tools. Compared to HA, HA-NP exhibited an enhanced stability against HYAL1 degradation while maintaining its interaction with the HA receptors CD44 and aggrecan. HA-NP displayed a strong and selective inhibition of HYAL1 activity and retarded the hydrolysis of higher-molar-mass HA in solution. A co-nanoprecipitation process was used to formulate a range of hybrid nanoparticle samples, which demonstrated the specificity and efficiency of HA-NP in HYAL1 inhibition. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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    Haohao Duan, Mark Donovan, Franck Hernandez, Carmelo Di Primo, Elisabeth Garanger, Xavier Schultze, Sébastien Lecommandoux. Hyaluronic-Acid-Presenting Self-Assembled Nanoparticles Transform a Hyaluronidase HYAL1 Substrate into an Efficient and Selective Inhibitor. Angewandte Chemie (International ed. in English). 2020 Aug 03;59(32):13591-13596

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    PMID: 32363767

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