Modeling and simulation of excitation- contraction coupling of fast-twitch skeletal muscle fibers.

The current excitation-contraction coupling model of fast-twitch skeletal muscle fibers cannot completely simulate the excitation-contraction process. To solve this problem, this study proposes an excitation-contraction model of fast-twitch skeletal muscle fibers based on the physiological structure and contractile properties of half-sarcomeres. The model includes the action potential model of fast-twitch fiber membranes and transverse tubule membranes, the cycle model of 𝐶𝑎2+ in myofibril, the cross-bridge cycle model, and the fatigue model of metabolism. Finally, detailed analyses of the results from the simulation are conducted using the Simulink toolbox in MATLAB. Two conditions, non-coincidence and coincidence, are analyzed for both the thick and thin myofilaments. The simulation results of two groups of models are the same as the previous research results, which validates the accuracy of models.

Citation

Monan Wang, Jiangang Sun, Qiyou Yang. Modeling and simulation of excitation- contraction coupling of fast-twitch skeletal muscle fibers. Technology and health care : official journal of the European Society for Engineering and Medicine. 2020;28(S1):13-24

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PMID: 32364140

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