Biodegradable β-Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water-Insoluble Drug.

Advanced healthcare materials 2020 Jun

filter terms:

Transdermal delivery of water-insoluble drugs via hydrogel-based microneedle (MN) arrays is crucial for improving their therapeutic efficacies. However, direct loading of water-insoluble drug into hydrophilic matrices remains challenging. Here, a biodegradable MN array patch that is fabricated from naturally derived polymer conjugates of gelatin methacryloyl and β-cyclodextrin (GelMA-β-CD) is reported. When curcumin, an unstable and water-insoluble anticancer drug, is loaded as a model drug, its stability and solubility are improved due to the formation of an inclusion complex. The polymer-drug complex GelMA-β-CD/CUR can be formulated into MN arrays with sufficient mechanical strength for skin penetration and tunable drug release profile. Anticancer efficacy of released curcumin is observed in three-dimensional B16F10 melanoma models. The GelMA-β-CD/CUR MN exhibits relatively higher therapeutic efficacy through more localized and deeper penetrated manner compared with a control nontransdermal patch. In vivo studies also verify biocompatibility and degradability of the GelMA-β-CD MN arrays patch. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Xingwu Zhou, Zhimin Luo, Avijit Baidya, Han-Jun Kim, Canran Wang, Xing Jiang, Moyuan Qu, Jixiang Zhu, Li Ren, Fereshteh Vajhadin, Peyton Tebon, Niyuan Zhang, Yumeng Xue, Yudi Feng, Chengbin Xue, Yi Chen, KangJu Lee, Junmin Lee, Shiming Zhang, Chun Xu, Nureddin Ashammakhi, Samad Ahadian, Mehmet Remzi Dokmeci, Zhen Gu, Wujin Sun, Ali Khademhosseini. Biodegradable β-Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water-Insoluble Drug. Advanced healthcare materials. 2020 Jun;9(11):e2000527