Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

No randomized controlled clinical trial of therapeutic plasma exchanges (TPE) has yet been performed for moderate-to-severe relapses of multiple sclerosis (MS). To compare TPE to sham-TPE in patients with a recent steroid-resistant moderate-to-severe MS relapse. Patients presenting with an MS relapse of less than 2 months without improvement and 15 days after a course of steroids were randomized. Specific criteria were used for each relapse type to define moderate-to-severe disability. The primary endpoint was the proportion of patients with at least a moderate improvement based on objective and functional evaluation after 1 month. Thirty-eight patients were randomized. The intention-to-treat analysis included 14 patients in the TPE group and 17 in the Sham-TPE group. The proportion of patients with at least moderate improvement at 1 month did not differ between the groups (P = .72), although 57.1% of the TPE group had full recovery compared with 17.6% of the sham group. Considering optic neuritis (ON), a significant difference in the proportion of different levels of improvement was observed in favor of the TPE group (P = .04). The combined Kurtzke's functional systems scores were significantly more improved in the TPE group than in the sham-TPE group at months 1 (P < .01), 3 (P < .05), and 6 (P < .05). No major side effects were observed. A significant difference between TPE and Sham-TPE at the primary endpoint was only observed in patients with ON. Neurological function improved significantly more often in the TPE group than in the sham-TPE group. © 2020 Wiley Periodicals, Inc.


Bruno Brochet, Mathilde Deloire, Christine Germain, Jean-Christophe Ouallet, Linda Wittkop, Cécile Dulau, Paul Perez, Florian Thevenot, Jérome De Sèze, Hélène Zéphir, Patrick Vermersch, Sophie Pittion, Marc Debouverie, David-Axel Laplaud, Pierre Clavelou, Aurélie Ruet. Double-blind, randomized controlled trial of therapeutic plasma exchanges vs sham exchanges in moderate-to-severe relapses of multiple sclerosis. Journal of clinical apheresis. 2020 Aug;35(4):281-289

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 32369661

View Full Text