New work describes a novel mechanism of mechanotransduction, whereby force-induced membrane deformation activates integrins by disrupting the association of the transmembrane domains of α and β integrins. Copyright © 2020 Elsevier Inc. All rights reserved.
Alexandre R Gingras, Mark H Ginsberg. Signal Transduction: Physical Deformation of the Membrane Activates Integrins. Current biology : CB. 2020 May 04;30(9):R397-R400
PMID: 32369751
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