Dynamic catch-bonding generates the large stall forces of cytoplasmic dynein.

Christopher M Johnson, J Daniel Fenn, Anthony Brown, P Jung

Physical biology 2020 Jun 19

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Cytoplasmic dynein is an important molecular motor involved in the transport of vesicular and macromolecular cargo along microtubules in cells, often in conjunction with kinesin motors. Dynein is larger and more complex than kinesin and the mechanism and regulation of its movement is currently the subject of intense research. While it was believed for a long time that dynein motors are relatively weak in terms of the force they can generate, recent studies have shown that interactions with regulatory proteins confer large stall forces comparable to those of kinesin. This paper reports on a theoretical study which suggests that these large stall forces may be the result of an emergent, ATP-dependent, bistability resulting in a dynamic catch-bonding behavior that can cause the motor to switch between high and low load-force states.

Citation

Christopher M Johnson, J Daniel Fenn, Anthony Brown, P Jung. Dynamic catch-bonding generates the large stall forces of cytoplasmic dynein. Physical biology. 2020 Jun 19;17(4):046004