Clear Search sequence regions


  • adult (1)
  • bladder (2)
  • bladder pain (2)
  • control groups (3)
  • cystitis (5)
  • diagnosis (1)
  • female (1)
  • humans (1)
  • men (1)
  • patients (8)
  • ulcer (1)
  • uroplakin (4)
  • urothelium (5)
  • visual analogue scale (2)
  • western blot (1)
  • women (1)
  • Sizes of these terms reflect their relevance to your search.

    We evaluated changes in the expression of uroplakin (UP) in the urothelium of patients with ulcerative interstitial cystitis/bladder pain syndrome (IC/BPS). Bladder samples were collected from 19 patients with ulcerative IC/BPS who were treated with augmentation ileocystoplasty and from 5 control patients. Frequency-volume charts, the pain visual analogue scale (VAS), and the O'Leary-Sant interstitial cystitis symptom index (ICSI) and problem index (ICPI) were used to evaluate the patients' symptoms preoperatively. The expression levels of UP-Ib and UP-III in the urothelium were compared between the IC/BPS patients and control patients. Sixteen women and three men with IC/BPS were evaluated. Their values for preoperative mean voiding frequency, number of nocturia episodes, and functional bladder capacity as recorded in frequency-volume charts were 21.1±12.8, 5.9±4.2, and 151.1±62.7 mL, respectively. The mean pain VAS, ICSI, and ICPI scores were 8.4±1.3, 17.7±2.2, and 14.7±1.8, respectively. Immunofluorescence staining showed that UP-Ib and UP-III were localized in the urothelium. Upon Western blot analysis, the expression of UP-III was significantly increased in the IC/BPS group compared with the control group. However, expression of UP-Ib did not differ significantly between the IC/BPS and control groups. UP-III was significantly upregulated in patients with ulcerative IC/BPS. UP-III is a potential biomarker for the diagnosis of ulcerative IC/BPS. © The Korean Urological Association, 2020.

    Citation

    Kang Jun Cho, Kyu-Sung Lee, Jin Bong Choi, Jun Sung Koh, Joon Chul Kim. Changes in uroplakin expression in the urothelium of patients with ulcerative interstitial cystitis/bladder pain syndrome. Investigative and clinical urology. 2020 May;61(3):304-309

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 32377607

    View Full Text