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Total Synthesis of Echinomycin and Its Analogues.
Keita Kojima, Fumika Yakushiji, Akira Katsuyama, Satoshi Ichikawa
Organic letters 2020 Jun 05Sizes of these terms reflect their relevance to your search.
The first total synthesis of echinomycin (1) was accomplished by featuring the late-stage construction of the thioacetal moiety via Pummerer rearrangement and simultaneous cyclization, as well as two-directional elongation of the peptide chains to construct a C2-symmetrical bicyclic octadecadepsipeptide bridged with a sulfide linkage. This strategy can be applicable to a variety of echinomycin analogues.
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Keita Kojima, Fumika Yakushiji, Akira Katsuyama, Satoshi Ichikawa. Total Synthesis of Echinomycin and Its Analogues. Organic letters. 2020 Jun 05;22(11):4217-4221
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PMID: 32379459
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