Correlation Engine 2.0
Clear Search sequence regions

  • chickens (1)
  • coturnix (1)
  • humans (1)
  • hypothalamus (3)
  • oxyntomodulin (9)
  • proglucagon (1)
  • quail (5)
  • random (1)
  • weight loss (1)
  • Sizes of these terms reflect their relevance to your search.

    Oxyntomodulin (OXM) is a proglucagon-derived peptide that suppresses hunger in humans. There are some differences in its food intake-inhibitory effects among species. The central mechanisms are unclear and it is unknown if OXM is more efficacious in a gallinaceous species that has not undergone as much selection for growth as the chicken. The objective was thus to determine the effects of OXM on food and water intake and hypothalamic physiology in Japanese quail. At 7 days post-hatch, 6-h-fasted quail were injected intracerebroventricularly (ICV) or intraperitoneally (IP) with 0.32, 0.65, or 1.3 nmol of OXM. All doses decreased food intake for 180 min post-ICV injection. On a cumulative basis, water intake was not affected until 120 min, with the lowest and highest doses decreasing water intake after ICV injection. The two highest doses were anorexigenic when administered via the IP route, whereas all doses were anti-dipsogenic starting at 30 min post-injection. In hypothalamic samples collected at 1-h post-ICV injection, there was an increase in c-Fos immunoreactivity, an indicator of recent neuronal activation, in the arcuate nucleus (ARC) and dorsomedial nucleus (DMN) of the hypothalamus in OXM-injected individuals. Results suggest that quail are more sensitive than chickens to the satiety-inducing effects of OXM. The central mechanism is likely mediated through a pathway in the ARC that is conserved among species, and through activation of the DMN, an effect that is unique to quail. Such knowledge is critical for facilitating the development of novel, side effect-free anti-eating strategies to promote weight-loss in obesity. Copyright © 2020 Elsevier Inc. All rights reserved.


    Bailey Halter, Vishwajit S Chowdhury, Elizabeth R Gilbert, Mark A Cline. Oxyntomodulin induces satiety and activates the arcuate nucleus of the hypothalamus in Japanese quail. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2020 Sep;247:110721

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 32380163

    View Full Text