Glyphosate exposure exacerbates the dopaminergic neurotoxicity in the mouse brain after repeated administration of MPTP.

Yaoyu Pu, Lijia Chang, Youge Qu, Siming Wang, Yunfei Tan, Xingming Wang, Jiancheng Zhang, Kenji Hashimoto

Neuroscience letters 2020 Jun 21

filter terms:

Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder. Epidemiological studies suggest that the exposure of the herbicide glyphosate may influence the development of PD in humans. In this study, we examined whether the exposure of glyphosate can affect the reduction of dopamine transporter (DAT) in the striatum and tyrosine hydroxylase (TH) in the substantial nigra (SNr) of mouse brain after repeated administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Repeated injections of MPTP (10 mg/kg × 3, 2-h interval) significantly decreased the density of DAT-immunoreactivity in the striatum and the number of TH-immunoreactivity in the SNr. Glyphosate exposure for 14 days significantly potentiated MPTP-induced dopaminergic neurotoxicity in the striatum and SNr of mouse brain. This study suggests that glyphosate exposure might exacerbate MPTP-induced dopaminergic neurotoxicity in the striatum and SNr of adult mice. It is likely that exposure of glyphosate may be an environmental risk factor for PD since glyphosate has been used widely in the world. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Yaoyu Pu, Lijia Chang, Youge Qu, Siming Wang, Yunfei Tan, Xingming Wang, Jiancheng Zhang, Kenji Hashimoto. Glyphosate exposure exacerbates the dopaminergic neurotoxicity in the mouse brain after repeated administration of MPTP. Neuroscience letters. 2020 Jun 21;730:135032