One-pot cascade synthesis of benzopyrans and dihydropyrano[c]chromenes catalyzed by lipase TLIM.

Yajie Fu, Zeping Lu, Xiaolong Ma, Ke Fang, Xinyi He, Huajin Xu, Yi Hu

Bioorganic chemistry 2020 Jun

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Lipase TLIM was reported to be an efficient, commercially available and reusable catalyst for the Knoevenagel-Michael cascade reactions of aldehydes, malononitrile/ethyl cyanoacetate and 4-hydroxycoumarin/1, 3-cyclohexanedione/dimedone in aqueous DMSO. This methodology presents many superiorities such as simple procedure, mild reaction conditions, commercially available and reusable catalyst, high substrate applicability, the ability to be scaled up, and good to excellent yields. Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Yajie Fu, Zeping Lu, Xiaolong Ma, Ke Fang, Xinyi He, Huajin Xu, Yi Hu. One-pot cascade synthesis of benzopyrans and dihydropyrano[c]chromenes catalyzed by lipase TLIM. Bioorganic chemistry. 2020 Jun;99:103888