Soluble Interleukin-2 Receptor Index Predicts Outcomes After Cord Blood Transplantation.

Our previous study demonstrated that the soluble interleukin-2 receptor (sIL-2R) index, defined as the ratio of serum sIL-2R levels at neutrophil engraftment to that before conditioning, is a biomarker that can predict acute graft-vs-host disease (GVHD) after unrelated bone marrow transplantation. In the present study, we evaluated the significance of the sIL-2R index among patients who underwent cord blood transplantation (CBT). We retrospectively analyzed 31 patients who underwent single-unit CBT as their first transplantation for hematologic malignancies. The median sIL-2R index was 4.2. The cumulative incidence of grade II to IV acute GVHD was not associated with the sIL-2R index. However, the cumulative incidence of relapse at 3 years after transplantation was significantly lower, with an sIL-2R index ≥ 3.7 than with an index < 3.7 (12.8% vs 50.0%; P = .04). As a result, the probability of overall survival at 3 years after transplantation was significantly higher in the former group than in the latter (79.8% vs 20.0%; P < .01). Only the dose of corticosteroid administered in the pre-engraftment period influenced the sIL-2 index. The sIL-2R index can predict the incidence of relapse and probability of survival after CBT, possibly reflecting a graft-vs-leukemia effect. Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Yasuko Kajimura, Yukinori Nakamura, Yoshinori Tanaka, Mayumi Tanaka, Kaoru Yamamoto, Masafumi Matsuguma, Yoshihiro Tokunaga, Toshiaki Yujiri, Yukio Tanizawa. Soluble Interleukin-2 Receptor Index Predicts Outcomes After Cord Blood Transplantation. Transplantation proceedings. 2021 Jan-Feb;53(1):379-385

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PMID: 32389487

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