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The cold neutron beam at the PF1b line at the Institut Laue-Langevin (ILL), without fast neutrons and a low contribution of gamma rays, is a very suitable facility to measure cell damage following low-energy neutron irradiation. The biological damage associated with the thermal and the boron doses can be obtained in order to evaluate the relative biological effectiveness (RBE) for Boron Neutron Capture Therapy. Three different experiments were carried out on the A375 melanoma cell line: the first one in a hospital LINAC, to obtain the reference radiation data, and the other two at the ILL, in which the damage to cells with and without boron compounds added was measured. Copyright © 2020. Published by Elsevier Ltd.


María Pedrosa-Rivera, M José Ruiz-Magaña, Patricia Álvarez, Ignacio Porras, Javier Praena, Manuel P Sabariego, Ulli Köster, Michael Haertlein, V Trevor Forsyth, Torsten Soldner, José C Ramírez, Clara Jover, Daniel Jimena, Juan L Osorio, Ian Postuma, Carmen Ruiz-Ruiz. Radiobiology data of melanoma cells after low-energy neutron irradiation and boron compound administration. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2020 Sep;163:109205

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PMID: 32392166

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