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Chronic spontaneous urticaria (CSU) is a chronic disease with an unknown etiology. In human leukocyte antigen (HLA) system, the association of class I and class II antigens with autoimmune diseases has been identified and HLA antigens that have a tendency to or can prevent chronic urticaria have been studied. The aim of this study is to investigate the association between chronic spontaneous urticaria and HLA class I and class II antigens. A total of 80 subjects, 40 patients with CSU and 40 healthy individuals were enrolled in the study. DNA sample isolation from blood was primarily done by the real-time polymerase chain reaction (RT-PCR) technique for the first time. Using HLA SSP Typing Kit (ROSE Cat. No: 800118) PCR technique, HLA-A, B, C, DRB and DQB alleles from DNA samples were analyzed. The mean age was 36.80 ± 9.48 years and the duration of the disease was 4.26 ± 5.18 years. Among the HLA class I and class II antigens, HLA-A was detected significantly more often in the control group (P = 0.039). HLA-DRB1 was more often detected in the CSU group but no statistical difference (P > 0.05). It can be considered that HLA-DRB1 may have a tendency to CSU, while HLA-A might prevent the disease. This work is licensed under a Creative Commons Attribution 4.0 International License.


Neslihan Doğan, Songül Çildağ, Çiğdem Yenisey, Taşkin Şentürk. The association between chronic spontaneous urticaria and HLA class I and class II antigen Turkish journal of medical sciences. 2020 Aug 26;50(5):1231-1235

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PMID: 32394676

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