Correlation Engine 2.0
Clear Search sequence regions


  • alpaca (9)
  • BMP4 (2)
  • COL1A2 (1)
  • fiber (2)
  • GLI1 (1)
  • ncRNA (1)
  • peru (1)
  • protein- genes (1)
  • sex chromosomes (2)
  • SFRP4 (1)
  • SNPs (1)
  • wool (1)
  • x chromosome (1)
  • Sizes of these terms reflect their relevance to your search.

    Alpaca is a camelid species of broad economic, biological and biomedical interest, and an essential part of the cultural and historical heritage of Peru. Recently, efforts have been made to improve knowledge of the alpaca genome, and its genetics and cytogenetics, to develop molecular tools for selection and breeding. Here, we report cytogenetic mapping of 35 new markers to 19 alpaca autosomes and the X chromosome. Twenty-eight markers represent alpaca SNPs, of which 17 are located inside or near protein-coding genes, two are in ncRNA genes and nine are intergenic. The remaining seven markers correspond to candidate genes for fiber characteristics (BMP4, COL1A2, GLI1, SFRP4), coat color (TYR) and development (CHD7, PAX7). The results take the tally of cytogenetically mapped markers in alpaca to 281, covering all 36 autosomes and the sex chromosomes. The new map assignments overall agree with human-camelid conserved synteny data, except for mapping BMP4 to VPA3, suggesting a hitherto unknown homology with HSA14. The findings validate, refine and correct the current alpaca assembly VicPac3.1 by anchoring unassigned sequence scaffolds, and ordering and orienting assigned scaffolds. The study contributes to the improvement in the alpaca reference genome and advances camelid molecular cytogenetics.

    Citation

    Mayra N Mendoza, Terje Raudsepp, Manuel J More, Gustavo A Gutiérrez, F Abel Ponce de León. Cytogenetic Mapping of 35 New Markers in the Alpaca (Vicugna pacos). Genes. 2020 May 08;11(5)

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 32397072

    View Full Text