Ribosomal incorporation of cyclic β-amino acids into peptides using in vitro translation.

We demonstrate in vitro incorporation of cyclic β-amino acids into peptides by the ribosome through genetic code reprogramming. Further, we show that incorporation efficiency can be increased through the addition of elongation factor P.

Citation

Joongoo Lee, Rafael Torres, Do Soon Kim, Michelle Byrom, Andrew D Ellington, Michael C Jewett. Ribosomal incorporation of cyclic β-amino acids into peptides using in vitro translation. Chemical communications (Cambridge, England). 2020 May 27;56(42):5597-5600

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PMID: 32400780

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