Encapsulated DNase improving the killing efficiency of antibiotics in staphylococcal biofilms.

Chenhui Liu, Yu Zhao, Wanqi Su, Jingshan Chai, Lina Xu, Jingjing Cao, Yang Liu

Journal of materials chemistry. B 2020 May 28

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We developed a polymer-encapsulated DNase, n(DNase), which can efficiently accumulate in biofilm and expose the DNase to cleave the eDNA of the biofilm. CLSM and crystal violet staining results demonstrated effective biofilm disintegration (92.2%) when treated with n(DNase). This work demonstrated a general approach for coating matrix-dispersion enzymes to achieve biofilm disintegration and provided a promising strategy for treating biofilm-associated infections.

Citation

Chenhui Liu, Yu Zhao, Wanqi Su, Jingshan Chai, Lina Xu, Jingjing Cao, Yang Liu. Encapsulated DNase improving the killing efficiency of antibiotics in staphylococcal biofilms. Journal of materials chemistry. B. 2020 May 28;8(20):4395-4401