Establishing correct kinetochore-microtubule attachments in mitosis and meiosis.

Gisela Cairo, Soni Lacefield

Essays in biochemistry 2020 Sep 04

filter terms:

Faithful chromosome segregation in mitosis and meiosis requires that chromosomes properly attach to spindle microtubules. Initial kinetochore-microtubule attachments are often incorrect and rely on error correction mechanisms to release improper attachments, allowing the formation of new attachments. Aurora B kinase and, in mammalian germ cells, Aurora C kinase function as the enzymatic component of the Chromosomal Passenger Complex (CPC), which localizes to the inner centromere/kinetochore and phosphorylates kinetochore proteins for microtubule release during error correction. In this review, we discuss recent findings of the molecular pathways that regulate the chromosomal localization of Aurora B and C kinases in human cell lines, mice, fission yeast, and budding yeast. We also discuss differences in the importance of localization pathways between mitosis and meiosis. © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Citation

Gisela Cairo, Soni Lacefield. Establishing correct kinetochore-microtubule attachments in mitosis and meiosis. Essays in biochemistry. 2020 Sep 04;64(2):277-287