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    Twelve new sesterterpenes along with eight known sesterterpenes were isolated from the marine sponge Hyrtios erectus collected off the coast of Chuuk Island, the Federated State of Micronesia. Based upon a combination of spectroscopic and computational analyses, these compounds were determined to be eight glycine-bearing scalaranes (1-8), a 3-keto scalarane (9), two oxidized-furan-bearing scalaranes (10 and 11), and a salmahyrtisane (12). Several of these compounds exhibited weak antiproliferation against diverse cancer cell lines as well as moderate anti-angiogenesis activities. The antiproliferative activity of new compound 4 was found to be associated with G0/G1 arrest in the cell cycle.


    Oh-Seok Kwon, Donghwa Kim, Chang-Kwon Kim, Jeongyoon Sun, Chung J Sim, Dong-Chan Oh, Sang Koo Lee, Ki-Bong Oh, Jongheon Shin. Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios erectus. Marine drugs. 2020 May 13;18(5)

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    PMID: 32414015

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