Atypical cyclins in cancer: New kids on the block?

Eva Quandt, Mariana P C Ribeiro, Josep Clotet

Seminars in cell & developmental biology 2020 Nov

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Atypical cyclins have recently emerged as a new subfamily of cyclins characterized by common structural features and interactor pattern. Interestingly, atypical cyclins are phylogenetically close to canonical cyclins, which have well-established roles in cell cycle regulation and cancer. Therefore, although the function of atypical cyclins is still poorly characterized, it seems likely that they are involved in cancer pathogenesis as well. Here, we coupled gene expression and prognostic significance analysis to bibliographic search in order to provide new insights into the role of atypical cyclins in cancer. The information gathered suggests that atypical cyclins intervene in critical processes to sustain cancer growth and have potential to become novel prognostic markers and drug targets in cancer. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Eva Quandt, Mariana P C Ribeiro, Josep Clotet. Atypical cyclins in cancer: New kids on the block? Seminars in cell & developmental biology. 2020 Nov;107:46-53