Systemic Regulation of Local Cell Competition.

Susumu Hirabayashi, Ross Cagan

Developmental cell 2020 May 18

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Somatic scribble mutant cells are selectively eliminated from the growing Drosophila tissue through cell competition, a tumor-suppressing mechanism that ensures tissue integrity. In this issue of Developmental Cell, Sanaki et al. demonstrate that organismal hyperinsulinemia promotes tumorigenesis by abrogating local cell competition. Copyright © 2020. Published by Elsevier Inc.