Correlation Engine 2.0
Clear Search sequence regions

  • adult (4)
  • cells blood (1)
  • cells progenitors (2)
  • embryo mammalian (1)
  • embryos (2)
  • endocardium (2)
  • endothelium (7)
  • GATA4 (6)
  • heart (1)
  • liver (1)
  • mesoderm (1)
  • mice (1)
  • myocardium (1)
  • neonates (1)
  • newborn (1)
  • Sizes of these terms reflect their relevance to your search.

    Different sources have been claimed for the embryonic origin of the coronary endothelium. Recently, the potential of circulating cells as progenitors of the cardiac endothelium has also been suggested. In a previous study we have shown that circulating progenitors are recruited by the embryonic endocardium and incorporated into the coronary vessels. These progenitors derive from a mesodermal lineage characterized by the expression of Gata4 under control of the enhancer G2. Herein, we aim to trace this specific lineage throughout postnatal stages. We have found that more than 50% of the adult cardiac endothelium derives from the G2-GATA4 lineage. This percentage increases from embryos to adults probably due to differential proliferation and postnatal recruitment of circulating endothelial progenitors. In fact, injection of fetal liver or placental cells in the blood stream of neonates leads to incorporation of G2-GATA4 lineage cells to the coronary endothelium. On the other hand, labeling of the hematopoietic lineage by the stage E7.5 also resulted in positive coronary endothelial cells from both, embryos and adults. Our results suggest that early hematopoietic progenitors recruited by the embryonic ventricular endocardium can become the predominant source of definitive endothelium during the vascularization of the heart.


    Rita Carmona, Sandra Díaz Del Moral, Silvia Barrena, Ramón Muñoz-Chápuli. Contribution of a GATA4-Expressing Hematopoietic Progenitor Lineage to the Adult Mouse Endothelium. Cells. 2020 May 19;9(5)

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 32438714

    View Full Text