Comparison between intravenous lidocaine and fentanyl on cough reflex and sympathetic response during endotracheal intubation in dogs.

Veronica Re Bravo, Nunzia Palomba, Federico Corletto, Ruth Willis, Enzo Vettorato

Veterinary anaesthesia and analgesia 2020 Jul

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To compare the effects of intravenous (IV) lidocaine and fentanyl on the cough reflex and autonomic response during endotracheal intubation in dogs. Randomized, blinded, superiority clinical trial. A total of 46 client-owned dogs undergoing magnetic resonance imaging. After intramuscular methadone (0.2 mg kg-1), dogs were randomized to be administered either IV lidocaine (2 mg kg-1; group L) or fentanyl (7 μg kg-1; group F). After 5 minutes, alfaxalone was administered until endotracheal intubation was possible (1 mg kg-1 IV over 40 seconds followed by 0.4 mg kg-1 increments to effect). Total dose of alfaxalone was recorded and cough reflex at endotracheal intubation was scored. Heart rate (HR) was continuously recorded, Doppler systolic arterial blood pressure (SAP) was measured every 20 seconds. Vasovagal tonus index (VVTI) and changes (Δ) in HR, SAP and VVTI between pre-intubation and intubation were calculated. Groups were compared using univariate and multivariate analysis. Statistical significance was set as p < 0.05. Group F included 22 dogs and group L 24 dogs. The mean (± standard deviation) alfaxalone dose was 1.1 (± 0.2) and 1.35 (± 0.3) mg kg-1 in groups F and L, respectively (p = 0.0008). At intubation, cough was more likely in group L (odds ratio = 11.3; 95% confidence intervals, 2.1 - 94.2; p = 0.01) and HR increased in 87.5% and 54.5% of groups L and F, respectively (p = 0.02). The median (range) ΔHR between pre-intubation and intubation was higher (13.1%; - 4.3 to + 55.1) in group L (p = 0.0021). Between groups, SAP and VVTI were similar. At the stated doses, whilst reducing the alfaxalone dose, fentanyl is superior to lidocaine in suppressing the cough reflex and blunting the increase in HR at endotracheal intubation in dogs premedicated with methadone. Copyright © 2020 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.

Citation

Veronica Re Bravo, Nunzia Palomba, Federico Corletto, Ruth Willis, Enzo Vettorato. Comparison between intravenous lidocaine and fentanyl on cough reflex and sympathetic response during endotracheal intubation in dogs. Veterinary anaesthesia and analgesia. 2020 Jul;47(4):481-489