Furan fragment isomerized andirobin-type limonoids from the stem barks of Khaya senegalensis.

Yun-Ge Bu, Wen-Yan Zhang, Qin-Pei Lu, Jun Luo, Ling-Yi Kong

Journal of Asian natural products research 2021 May

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A new andirobin-type limonoid with modified furan ring, khaysenelide K (1), together with a known analogue (2), was isolated from the stem barks of Khaya senegalensis. The structure and absolute configuration of 1 were elucidated by a combination of 1D and 2D NMR, HRESIMS, and single-crystal X-ray diffraction using mirror Cu-Kα radiation. Compound 1 showed moderate NO inhibitory activity in LPS-activated RAW 264.7 macrophages with IC50 value of 27.74 ± 0.68 μM.[Formula: see text].

Citation

Yun-Ge Bu, Wen-Yan Zhang, Qin-Pei Lu, Jun Luo, Ling-Yi Kong. Furan fragment isomerized andirobin-type limonoids from the stem barks of Khaya senegalensis. Journal of Asian natural products research. 2021 May;23(5):498-503