Correlation Engine 2.0
Clear Search sequence regions

  • cellular (2)
  • danger (4)
  • host cells (1)
  • humans (1)
  • macrophages (4)
  • signals (1)
  • Sizes of these terms reflect their relevance to your search.

    In this review, we propose that certain modifications in cellular metabolism might function as danger signals triggering inflammasome-mediated immune responses. We propose to call them danger-associated metabolic modifications (DAMMs). As intracellular bacteria can actively modulate macrophage metabolism for their benefit, infected host cells might sense bacteria-induced metabolic alterations and activate immune reactions. Here we report the known metabolic interactions that occur during infection of macrophages by intracellular bacteria and discuss the possible emergence of DAMMs upon bacteria-induced alterations of cellular metabolism. © The Japanese Society for Immunology. 2020. All rights reserved. For permissions, please e-mail:


    Mariatou Dramé, Carmen Buchrieser, Pedro Escoll. Danger-associated metabolic modifications during bacterial infection of macrophages. International immunology. 2020 Jun 26;32(7):475-483

    Expand section icon Mesh Tags

    PMID: 32441740

    View Full Text