Identification of the AQP8-miR-92a network associated with the aggressive traits of colorectal cancer.

Even though earlier reports have revealed that Aquaporin 8 (AQP8) exert essential roles in diverse malignancies, its relationship between specific microRNAs (miRNAs) in regulation of colorectal carcinoma (CRC) progression has never been elaborated. Herein, we proved that AQP8 was downregulated in CRC and high level of AQP8 was significantly associated with better survival in CRC patients. Overexpression of AQP8 restrained CRC cell proliferation, migration and invasion capacities in vitro. In vivo, upregulation of AQP8 also suppressed CRC cell growth. Mechanistic analyses illustrated that AQP8 was a directly target of miR-92a. The expression of AQP8 was negatively modulated by miR-92a. Rescues analysis indicated that miR-92a facilitated CRC cell growth and invasion via modulating the expression of AQP8. Our work validated that miR-92a regulated the aggressiveness of CRC cell via targeting AQP8. Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

Hui Zhang, Wen Bo Du, Xiao Min Guo, Li Kang Wang, Jun Mei Cheng, Li Jing Wei. Identification of the AQP8-miR-92a network associated with the aggressive traits of colorectal cancer. Biochemical and biophysical research communications. 2020 Jun 18;527(1):218-225

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PMID: 32446370

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