Regioselective synthesis and anticancer evaluation of H2O2-activable nucleosides.

Ying-Jie Sun, Li Liu, Liang Cheng

Chemical communications (Cambridge, England) 2020 Jun 16

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We describe here the design, synthesis, and biological evaluation of H2O2-activatable nucleosides via an efficient and regioselective functionalization of unprotected precursors. Biological evaluation of a H2O2-specific responsive prodrug of gemecitabin demonstrates an extremely fast activation, low toxicity and enhanced anticancer effects in two cell lines.

Citation

Ying-Jie Sun, Li Liu, Liang Cheng. Regioselective synthesis and anticancer evaluation of H2O2-activable nucleosides. Chemical communications (Cambridge, England). 2020 Jun 16;56(48):6484-6487