Digoxin: Pharmacology and toxicology-A review.

Jiri Patocka, Eugenie Nepovimova, Wenda Wu, Kamil Kuca

Environmental toxicology and pharmacology 2020 Oct

filter terms:

Digoxin is a cardiac glycoside used as drug in case of heart problems, including congestive heart failure, atrial fibrillation or flutter, and certain cardiac arrhythmias. It has a very narrow therapeutic window of the medication. Digoxin is toxic substance with well known cardiotoxic effect. In this work, pharmacology and toxicology of digoxin are summarized; Its pharmacokinetics, pharmacodynamics, available acute toxicity data (different species, different administration routes) are summarized in this article. Moreover, its treatment side effect and human poisonings are thoroughly discussed. Finally, appropriate therapy regimen is proposed. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Jiri Patocka, Eugenie Nepovimova, Wenda Wu, Kamil Kuca. Digoxin: Pharmacology and toxicology-A review. Environmental toxicology and pharmacology. 2020 Oct;79:103400