Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-0440.

Taichi Ohshiro, Haruka Morita, Elyza Aiman Azizah Nur, Kanji Hosoda, Ryuji Uchida, Hiroshi Tomoda

The Journal of antibiotics 2020 Nov

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New compounds, designated voluhemins A (1) and B (2), are isolated from the culture broth of the fungal strain Volutella citrinella BF-0440 along with structurally related known NK12838 (3). Spectroscopic data, including 1D and 2D NMR, elucidated their structures. Compounds 1-3 have a common indoline-diterpene core and two additional isoprenyl moieties. Compounds 1 and 3 contain a hemiaminal unit, while 2 is O-methylated 1. Their inhibitory activities toward sterol O-acyltransferase (SOAT) 1 and 2 isozymes in SOAT1- and SOAT2-expressing Chinese hamster ovary (CHO) cells show that 2 selectively inhibits the SOAT2 isozyme.

Citation

Taichi Ohshiro, Haruka Morita, Elyza Aiman Azizah Nur, Kanji Hosoda, Ryuji Uchida, Hiroshi Tomoda. Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-0440. The Journal of antibiotics. 2020 Nov;73(11):748-755