The mannose 6-phosphate receptor targeted with porphyrin-based periodic mesoporous organosilica nanoparticles for rhabdomyosarcoma theranostics.

Biomaterials science 2020 Jul 07

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Porphyrin-based periodic mesoporous organosilica nanoparticles (PMO) synthesized from a large functional octatriethoxysilylated porphyrin precursor and allowing two-photon excitation photodynamic therapy (TPE-PDT) and NIR imaging were synthesized. These PMO were grafted with polyethylene glycol (PEG) moieties and an analogue of mannose 6-phosphate functionalized at the anomeric position (AMFA). AMFAs are known to efficiently target mannose 6-phosphate receptors (M6PRs) which are over-expressed in various cancers. Here, we demonstrated for the first time that M6PRs were over-expressed in rhabdomyosarcoma (RMS) cells and could be efficiently targeted with PMO-AMFA allowing TPE imaging and TPE-PDT of RMS cells. The comparison with healthy myoblasts demonstrated an absence of biological effects, suggesting a cancer cell specificity in the biomedical action observed.

Citation

Morgane Daurat, Christophe Nguyen, Sofia Dominguez Gil, Vincent Sol, Vincent Chaleix, Clarence Charnay, Laurence Raehm, Khaled El Cheikh, Alain Morère, Michele Bernasconi, Andrea Timpanaro, Marcel Garcia, Frédérique Cunin, Jochen Roessler, Jean-Olivier Durand, Magali Gary-Bobo. The mannose 6-phosphate receptor targeted with porphyrin-based periodic mesoporous organosilica nanoparticles for rhabdomyosarcoma theranostics. Biomaterials science. 2020 Jul 07;8(13):3678-3684