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RGEN Editing of RNA and DNA: The Long and Winding Road from Catalytic RNAs to CRISPR to the Clinic.
Cell 2020 May 28Sizes of these terms reflect their relevance to your search.
The first clinical studies utilizing RNA-guided endonucleases (RGENs) to therapeutically edit RNA and DNA in cancer patients were recently published. These groundbreaking technological advances promise to revolutionize genetic therapy and, as I discuss, represent the culmination of decades of innovative work to engineer RGENs for such editing applications. Copyright © 2020 Elsevier Inc. All rights reserved.
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Bruce A Sullenger. RGEN Editing of RNA and DNA: The Long and Winding Road from Catalytic RNAs to CRISPR to the Clinic. Cell. 2020 May 28;181(5):955-960
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PMID: 32470403
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