Trivalent metal complex geometry of the substrate governs cathepsin B enzymatic cleavage rate.

Shin Hye Ahn, James N Iuliano, Eszter Boros

Chemical communications (Cambridge, England) 2020 Jul 02

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The lysosomal protease cathepsin B recognizes defined, short peptide sequences, providing means for effective, targeted drug release. Here, we show that the introduction of a coordination complex adjacent to the cleavage sequence allows us to tune enzymatic cleavage rate by varying the complexed, trivalent metal ion.

Citation

Shin Hye Ahn, James N Iuliano, Eszter Boros. Trivalent metal complex geometry of the substrate governs cathepsin B enzymatic cleavage rate. Chemical communications (Cambridge, England). 2020 Jul 02;56(53):7289-7292