Nanoparticle-mediated double-stranded RNA delivery system: A promising approach for sustainable pest management.

Shuo Yan, Bin-Yuan Ren, Jie Shen

Insect science 2021 Feb

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RNA interference (RNAi) targeting lethal genes in insects has great potential for sustainable crop protection. Compared with traditional double-stranded (ds)RNA delivery systems, nanoparticles such as chitosan, liposomes, and cationic dendrimers offer advantages in delivering dsRNA/small interfering (si)RNA to improve RNAi efficiency, thus promoting the development and practice of RNAi-based pest management strategies. Here, we illustrate the limitations of traditional dsRNA delivery systems, reveal the mechanism of nanoparticle-mediated RNAi, summarize the recent progress and successful applications of nanoparticle-mediated RNAi in pest management, and finally address the prospects of nanoparticle-based RNA pesticides. © 2020 Institute of Zoology, Chinese Academy of Sciences.

Citation

Shuo Yan, Bin-Yuan Ren, Jie Shen. Nanoparticle-mediated double-stranded RNA delivery system: A promising approach for sustainable pest management. Insect science. 2021 Feb;28(1):21-34