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Tranexamic acid (TXA) is an important antihemorrhagic drug that needs a simple, sensitive and low cost spectrofluorimetric method for its determination. This method depends on generation of a yellow product which produced from a nucleophilic substitution reaction of the lone pair of electrons on the amino group found in the TXA chemical structure and 4-chloro-7-nitrobenzofurazan (NBD-Cl) in borate buffer PH 9.0. The product was measured at 536 nm (λex = 470.5 nm). All variables that have an effect on the formation and stability of the product have been explored and optimized. The linear range was 20-100 ng mL-1 with a limit of quantitation 12.4 ng mL-1. This method has been applied for assurance of tranexamic acid in ampoules and tablets dosage forms without any interference from excipients present. Also, we study the drug in human plasma. Copyright © 2020 Elsevier B.V. All rights reserved.


Mahmoud A Omar, Ebtehal F Anwer, Deena A M Nour El-Deen. Spectrofluorimetric approach for determination of tranexamic acid in pure form and pharmaceutical formulations; Application in human plasma. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Oct 05;239:118510

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PMID: 32480274

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