Mitochondrial ATP-sensitive potassium channel, MitoKATP, ameliorates mitochondrial dynamic disturbance induced by temporal lobe epilepsy.

Farnaz Nikbakht, Ali Mohammad Khanizadeh, Fereshteh Golab, Tourandokht Baluchnejadmojarad, Somayeh Vazifehkhah, Alireza Moeinsadat

Journal of chemical neuroanatomy 2021 Apr

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Temporal lobe epilepsy leads to a disturbance in the function and dynamic of the mitochondria. The mitoKATP channel is an important factor in controlling mitochondrial function. In this study, the protective role of mitoKATP was studied in temporal lobe epilepsy through the regulation of mitochondrial dynamic proteins. After induction of epilepsy, 5-HD (the inhibitor of mitoKATP) was administered daily for either 24 or 72 h. The results revealed an imbalance in dynamic proteins after epilepsy, specifically in the first 72 h. The disturbance in the mitochondrial dynamic worsened after blocking mitoKATP. In conclusion, mitoKATP has an important role in balancing mitochondrial dynamic proteins in epilepsy. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Farnaz Nikbakht, Ali Mohammad Khanizadeh, Fereshteh Golab, Tourandokht Baluchnejadmojarad, Somayeh Vazifehkhah, Alireza Moeinsadat. Mitochondrial ATP-sensitive potassium channel, MitoKATP, ameliorates mitochondrial dynamic disturbance induced by temporal lobe epilepsy. Journal of chemical neuroanatomy. 2021 Apr;113:101808