Two new triterpenoid-chromone hybrids from the rhizomes of Actaea cimicifuga L. (syn. Cimicifuga foetida L.) and their cytotoxic activities.

Qiang-Qiang Shi, Ya Gao, Jing Lu, Lin Zhou, Ming-Hua Qiu

Natural product research 2022 Jan

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Two new triterpenoid-chromone hybrids, cimitriteromones H (1) and I (2), along with two known analogues (3, 4) were isolated from the phytochemical research on the n-butyl alcohol extracts of Actaea cimicifuga rhizomes. The new compounds were elucidated by spectroscopic experiments and chemical method. The cytotoxic activities of the isolated compounds were tested on A-549/Taxol cell line. Cimitriteromone I (2) showed cytotoxicity with IC50 value of 27.14 ± 1.38 μM comparable to positive control group cisplatin (IC50 value of 25.80 ± 1.15 μM).

Citation

Qiang-Qiang Shi, Ya Gao, Jing Lu, Lin Zhou, Ming-Hua Qiu. Two new triterpenoid-chromone hybrids from the rhizomes of Actaea cimicifuga L. (syn. Cimicifuga foetida L.) and their cytotoxic activities. Natural product research. 2022 Jan;36(1):193-199