Isorhamnetin: A review of pharmacological effects.

Isorhamnetin is one of the most important active ingredients in the fruits of Hippophae rhamnoides L. and the leaves of Ginkgo biloba L., which possesses extensive pharmacological activities. At present, there have been numerous investigations on isorhamnetin, which has the effects of cardiovascular and cerebrovascular protection, anti-tumor, anti-inflammatory, anti-oxidation, organ protection, prevention of obesity, etc. The related mechanisms involve the regulation of PI3K/AKT/PKB, NF-κB, MAPK and other signaling pathways as well as the expression of related cytokines and kinases. Isorhamnetin has a high value of development and application. However, the investigations on its mechanism of action are limited and lack of detailed scientific validation. The manuscript reviewed the pharmacological effects of isorhamnetin and related mechanisms of action for the development of its medicinal properties further. Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Citation

Gang Gong, Ying-Yun Guan, Zhong-Lin Zhang, Khalid Rahman, Su-Juan Wang, Shuang Zhou, Xin Luan, Hong Zhang. Isorhamnetin: A review of pharmacological effects. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Aug;128:110301

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PMID: 32502837

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