The anti-inflammatory effect of miR-16 through targeting C- reactive protein is regulated by HuR in vascular smooth muscle cells.

Liang Liu

Biochemical and biophysical research communications 2020 Aug 06

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Atherosclerosis (AS) is the main pathological basis of coronary heart disease (CHD). Vascular smooth muscle cells (VMSCs) proliferation, migration and inflammatory response are the cytopathologic basis of AS. MiR-16 has been suggested to be closely associated with cell proliferation and inflammation. The regulatory role of the RNA binding protein HuR on miR-16 has been reported in colon cancer. However, the underlying roles of miR-16 on VMSCs and the regulatory function of HuR on miR-16 in VMSCs remain unknown. In this study, we found that the expression of miR-16 reduced and the expression of C-reactive protein and HuR increased when contractile VSMCs transformed into synthetic VMSCs. Furthermore, miR-16 impeded cell proliferation and inflammation via targeting CRP in VMSCs. HuR down-regulated miR-16 expression and impeded its influence on VMSCs. This study might provide an opportunity to develop a new effective target for the treatment of CHD. Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Liang Liu. The anti-inflammatory effect of miR-16 through targeting C- reactive protein is regulated by HuR in vascular smooth muscle cells. Biochemical and biophysical research communications. 2020 Aug 06;528(4):636-643