Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

In this study, the interfacial behavior of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine/1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (DPPC/DPPG) mixed monolayers with fluoxetine (FLX) in the subphase was investigated by a combination of the Langmuir-Blodgett technique and atomic force microscopy (AFM). It was found that DPPC/DPPG mixed monolayers showed different interfacial behaviors before and after addition of FLX in the subphase. The electrostatic interaction between FLX and lipids molecules destroys the homogeneity of the mixed monolayers and changes the arrangement of lipids molecules at the interface after addition of FLX in the subphase, thereby leading to an increase of compressibility and miscibility and a decrease in the stability of the mixed monolayers. The surface morphology of the mixed monolayers observed by AFM was different between without and with FLX in the subphase, indicating the penetration of FLX into the mixed monolayers. The present study has provided detailed information for further understanding the interactions of drugs with membrane lipids in other lipid monolayers.


Bin Xie, Changchun Hao, Ziyi Zhang, Runguang Sun. Studies on the interfacial behavior of DPPC/DPPG mixed monolayers in the presence of fluoxetine. Journal of molecular modeling. 2020 Jun 08;26(7):167

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 32514762

View Full Text