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In a recent issue of Nature, Lammert et al. demonstrate that DNA damage drives AIM2-mediated pyroptosis during normal brain development, preventing anxiety-like behaviors acquisition in adults and revealing an important role for non-apoptotic mechanisms of cell death during neurodevelopment. Copyright © 2020 Elsevier Inc. All rights reserved.
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Jaeda C Coutinho-Budd, Heather T Broihier. Pyroptosis Takes Aim at Neurodevelopment. Developmental cell. 2020 Jun 08;53(5):498-499
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PMID: 32516594
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