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In endothelial cells, trafficking of active α5β1 integrins and polarized fibronectin secretion are important for vascular morphogenesis. A new study unveils how the endothelial small GTPase RHOJ, by repressing trafficking of active α5β1 integrins, controls fibronectin polymerization and in vivo angiogenesis. Copyright © 2020 Elsevier Inc. All rights reserved.


Donatella Valdembri, Guido Serini. Angiogenesis: The Importance of RHOJ-Mediated Trafficking of Active Integrins. Current biology : CB. 2020 Jun 08;30(11):R652-R654

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PMID: 32516616

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