Chemical constituents from the Knema globularia fruits and their in vitro cytotoxicity.

Two new compounds, designated as knecorticosanones A-B (1-2), along with three known compounds (3-5) were isolated from the fruits of Knema globularia. Their structures were elucidated by extensive spectroscopy analysis, including 1D- and 2D-NMR, UV, IR, and HRESIMS and by comparison with the reported data in the literature. Compounds 1-5 were evaluated for their cytotoxicity. Knecorticosanone B (2) and malabaricone D (5) exhibited moderate cytotoxic effect against Hep-G2, MCF-7 and SK-LU-1 cell lines with IC50 values ranging from 8.76 ± 1.02 to 18.74 ± 1.75 μM while knecorticosanone A (1), virolane (3) and 7-hydroxy-3',4'-methylenedioxyflavan (4) exhibited weak inhibitory effect against these cell lines with IC50 values ranging from 25.85 ± 2.75 to 66.75 ± 2.08 μM.

Citation

Ty Viet Pham, Hieu Kim Thi Bach, Duc Viet Ho, Bao Chi Nguyen. Chemical constituents from the Knema globularia fruits and their in vitro cytotoxicity. Natural product research. 2022 Jan;36(1):256-262

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PMID: 32519564

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