Intra-arterial chemotherapy combined with VEC intravenous chemotherapy in the treatment of advanced retinoblastoma.

Kuifeng Xu, Junqi Liu, Chaojun Zhang

Journal of B.U.ON. : official journal of the Balkan Union of Oncology 2020 Mar-Apr

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To explore the efficacy and safety of intra-arterial chemotherapy (IAC) combined with vincristine + etoposide + carboplatin (VEC) intravenous chemotherapy (IVC) in the treatment of advanced retinoblastoma (RB). A total of 86 child patients (98 eyes) newly diagnosed with advanced RB (stage D and E), among whom 42 cases (49 eyes) underwent IVC and IAC combined with local ocular treatment (IVC+IAC group), and 44 cases (49 eyes) were treated with IAC combined with local ocular treatment (IAC group). At 4 weeks after treatment, the maximum diameter and thickness of the tumor were evaluated, the expression levels of serum markers [vascular endothelial growth factor (VEGF), neurone specific enolase (NSE), Livin and Survivin] were assessed. The maximum diameter and thickness of the tumor significantly declined in patients after treatment compared with those before treatment. The maximum diameter and thickness of the tumor in IVC+IAC group were significantly smaller than those in IAC group after treatment. In the two groups, the eye salvage rate was 85.7% (42/49) and 79.6% (39/49), respectively. The recurrence rate was 12.2% and 18.4%, respectively, and the metastasis and mortality rate were all 2.0%. The levels of serum VEGF, NSE, Livin and Survivin were obviously decreased in both groups after treatment compared with those before treatment, while they were significantly lower in IVC+IAC group than those in IAC group after treatment.

Citation

Kuifeng Xu, Junqi Liu, Chaojun Zhang. Intra-arterial chemotherapy combined with VEC intravenous chemotherapy in the treatment of advanced retinoblastoma. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2020 Mar-Apr;25(2):1199-1205