Zhi-Kang Duan, Tian-Ming Lv, Guan-Shan Song, Yu-Xi Wang, Bin Lin, Xiao-Xiao Huang
Natural product research 2022 JanTwo triterpenes (14S,17S,20S,24R)-25-hydroxy-14,17-cyclo-20,24-epoxy-malabarican-3-one (CEM, 1a) and (14S,17S,20S,24R)-20,24,25-trihydroxy-14,17-cyclomalabarican-3-one (CM, 2a) with a cyclobutane ring were reported, which have the same NMR data as ocotillone (1b) and gardaubryone C (2b), respectively. An incorrect structure might be reported. Therefore, the structure reanalysis of these triterpenes was achieved by CASE algorithm and DFT chemical shift predictions, and the results showed that the structures of CEM and CM might be incorrect. To further verify the structure of compound 1, the HMBC, 1H-1H COSY and HSQC-TOCSY spectra were employed. Herein, we revised the structure of CEM and CM, and our study also showed that CASE algorithm and DFT chemical shift predictions can hold the post of effective structure reassignment method.
Zhi-Kang Duan, Tian-Ming Lv, Guan-Shan Song, Yu-Xi Wang, Bin Lin, Xiao-Xiao Huang. Structure reassignment of two triterpenes with CASE algorithms and DFT chemical shift predictions. Natural product research. 2022 Jan;36(1):229-236
PMID: 32524840
View Full Text