Dewerin and gilbertionol two new secondary metabolites from the stem bark of Gilbertiodendron dewevrei (De Wild) J. Leonard.

The phytochemical investigation of the methanol extract of the stem bark of Gilbertiodendron dewevrei led to the isolation of two new secondary metabolites, 5,7-dihydroxy-4'-methoxyisoflavan-2,4-dione (1) and 23-hydroxy-2-tricosanone (2) along with 19 known compounds (3-21). The structure of these compounds were established by interpretation of their spectral data, mainly HR-TOFESIMS, 1 D NMR (1H, 13C and DEPT) and 2 D NMR (1H-1H COSY, HSQC, HMBC, and NOESY), and by comparison with those reported in the literature. The methanol extract and some isolates were screened for their antiradical, antibacterial, and inhibitory properties against acetylcholinesterase.

Citation

Dietagoum Madjouka Stephanie, Fongang Fotsing Yannick Stéphane, Bankeu Kezetas Jean Jules, Fatma Kaaniche, Isabelle Kamga Mawabo, Silvère Augustin Ngouela, Norbert Sewald, Bruno Ndjakou Lenta. Dewerin and gilbertionol two new secondary metabolites from the stem bark of Gilbertiodendron dewevrei (De Wild) J. Leonard. Natural product research. 2022 Jan;36(1):214-222

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PMID: 32524849

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